Almost forty years ago, a young girl of fourteen has sex, gets pregnant, and gives her baby up for adoption. Fast-forwarding to the present day, we meet three very different women, each of whom struggles to maintain control of their lives. There's Elizabeth, a smart and successful lawyer who uses her body to her advantage. Any time she feels that she doesn't have the upper hand, and cannot control the situation, she uses her sex appeal - whether that be starting a romance with her boss when she suspects he is trying to start one himself, or finding some way to control her overly friendly neighbor and husband. Karen, meanwhile, is a bitter health care professional who obviously has a lot of heart but never shows it. She gave up a daughter at the age of fourteen (wonderfully shown rather than told, she is the young girl and mother of Elizabeth), and has never gotten over it - her bitterness inspiring her to lash out at everyone around her...

After a plane crash, a young therapist, Claire, is assigned by her mentor to counsel the flight's five survivors. When they share their recollections of the incident -- which some say include an explosion that the airline claims never happened -- Claire is intrigued by Eric, the most secretive of the passengers. Just as Claire's professional relationship with Eric -- despite her better judgment -- blossoms into a romance, the survivors begin to disappear mysteriously, one by one. Claire suspects that Eric may hold all the answers and becomes determined to uncover the truth, no matter the consequences.